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Growth Suppression of Normal Mammary Epithelial Cells by Wild-Type p53

✍ Scribed by GIORGIO R. MERLO; TIZIANA VENESIO; DANIELA TAVERNA; ROBERT CALLAHAN; NANCY E. HYNES

Book ID
119868205
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
490 KB
Volume
698
Category
Article
ISSN
0890-6564

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Direct growth stimulation of normal huma
Direct growth stimulation of normal human epithelial cells by mutant p53
✍ Fiona S. Wyllie; Nick R. Lemoine; Claire M. Barton; Tim Dawson; Jane Bond; David πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 559 KB

## Abstract We developed a high‐titer amphotropic retroviral vector that expresses mutant (Ala 143) human __p53__ to test directly the response of genetically normal human epithelial cells to __p53__ mutation. Contrary to our prediction, we found that in pancreatic epithelium (whose tumors display