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Growth Retardation in Transgenic Mice Harboring a Type II Collagen Mutation

✍ Scribed by Mikko Savontaus; Eero Vuorio; Marjo Metsäranta


Book ID
119873822
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
412 KB
Volume
785
Category
Article
ISSN
0890-6564

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Skeletal development of transgenic mice with a type II collagen mutation was analyzed and compared with wild-type littermates. The single base substitution in Col2a1 resulted in a glycine to serine mutation within the helical domain and corresponded to one previously identified in a patient with the