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Growth inhibition by overexpression of human DEAD box protein rck/p54 in cells of a guinea pig cell line

✍ Scribed by Yukihiro Akao; Hiromi Mizoguchi; Nobuko Ohishi; Kunio Yagi


Book ID
117109272
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
272 KB
Volume
429
Category
Article
ISSN
0014-5793

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p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti