✦ LIBER ✦

Growth hormone stimulates insulin-like growth factor I actions on adult articular chondrocytes

✍ Scribed by Dr. R. Lane Smith; Marykutty V. Palathumpat; Christine W. Ku; Raymond L. Hintz

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 967 KB
Volume: 7
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.1100070207

No coin nor oath required. For personal study only.

✦ Synopsis

We report effects of adding insulin-like growth factor I (IGF-I) and methionyl human growth hormone (GH), alone or in combination, to adult bovine articular chondrocytes plated at high density. Purified human and synthetic IGF-I stimulated chondrocyte DNA and proteoglycan synthesis. GH had no effect on either process. However, GH added in combination with IGF-I increased proteoglycan, cell-associated proteoglycan, and keratan sulfate synthesis over levels observed with IGF-I alone. IGF-I and GH did not alter the hydrodynamic size of proteoglycans or synthesis of collagen. Our results show that GH and IGF-I act together to stimulate adult chondrocyte extracellular matrix synthesis.

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