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Growth hormone and insulin-like growth factor I concentrations in bulls of various growth hormone genotypes

✍ Scribed by P. Schlee; R. Graml; E. Schallenberger; D. Schams; O. Rottmann; A. Olbrich-Bludau; F. Pirchner

Publisher
Springer
Year
1994
Tongue
English
Weight
447 KB
Volume
88-88
Category
Article
ISSN
0040-5752

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✦ Synopsis

A leucine/valine substitution at amino acid position 127 was identified by the polymerase chain reaction and restriction fragment length polymorphism in the bovine growth hormone gene. Genotyping was performed in 84 AI bulls of three different breeds, in which plasma concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-1) were also measured. Gene frequencies of variants L (leucine) und V (valine) were 0.80/0.20 (Black and White), 0.90/0.10 (Brown), 0.71/0.29 (Simmental). Hormone concentrations were measured during different physiological conditions (normal feeding, fasting, realimentation) in the majority of animals. Generally, genotype LL was associated with higher concentrations of GH than LV. This difference was significant in Black and White bulls (P < 0.05). In contrast, IGF-1 concentrations were higher in LV than in LL animals. This was most pronounced in mature, realimented Simmental bulls. We conclude that the various GH alleles influence the circulating concentrations of GH and IGF-1.

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