This report demonstrates that the expression of melanoma growth stimulatory activity (MGSA) mRNA can be modulated in a positive fashion in the Hs294T human melanoma cell line by PDGF and MGSA. There is close correlation between MGSA expression and the pattern of cell growth in Hs294T cells.
Growth factor independence and growth regulatory pathways in human melanoma development
β Scribed by Ulrich Rodeck
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 714 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0167-7659
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The majority of ocular melanomas occur in the uveal tract. Chemotherapy is generally ineffective and large tumours requiring enucleation have a greater than 50% mortality at 5 years. Monosomy for chromosome 3 is common in uveal melanoma and it is known that there is loss of responsiveness to transfo
## Abstract Human tumors can constitutively express cytokines and growth factors, but the extent of this expression has not been investigated. Using 44 different probes to cytokines, growth factors, and their receptors, we tested 21 melanoma and 5 melanocyte cultures for RNA transcript expression b