## Abstract ## BACKGROUND Melanoma metastasizes by different mechanisms comprising direct invasion of the surrounding tissue and spreading via the lymphatic or vascular system. Despite their clinical relevance, the molecular mechanisms that guide the route of spreading and localization of the meta
Growth factor modulation of melanoma growth stimulatory activity mRNA expression in human malignant melanoma cells correlates with cell growth
β Scribed by R. Bordoni; G. Thomas; A. Richmond
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 497 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0730-2312
No coin nor oath required. For personal study only.
β¦ Synopsis
This report demonstrates that the expression of melanoma growth stimulatory activity (MGSA) mRNA can be modulated in a positive fashion in the Hs294T human melanoma cell line by PDGF and MGSA. There is close correlation between MGSA expression and the pattern of cell growth in Hs294T cells.
π SIMILAR VOLUMES
The functional role of epidermal growth factor (EGF) in epithelium-derived human colonic carcinoma cells was investigated by transfection with plasmid pUCDS3, which contained synthetic human EGF encoding sequences, into two human colonic carcinoma cell types with dissimilar phenotypic properties: th
a,-Macroglobulin ( a 2 M ) is known as an inhibitor of various proteinases and to bind several of the growth factors. W e previously demonstrated that clonal variation exists in the production of a,M in a human melanoma and that this variation may be associated with growth stimulation. We have now a
Reiterated selection in vivo of B16 murine melanoma cells for enhanced liver metastatic ability yielded a cell line (B16-LS9) dramatically overexpressing a constitutively active hepatocyte growth factor/scatter factor (HGF/SF) receptor, the product of the c-met proto-oncogene. Most likely because of