𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Growth characteristics of the stilbestrol-induced hamster kidney tumor

✍ Scribed by Jean B. Dekernion; Elwin E. Fraley

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
712 KB
Volume
3
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

The stilbestrol-induced hamster kidney tumor retained hormone dependence in vivo. In order to elucidate the mode and site of hormone stimulation, tumors of the twelfth in vivo transplant generation as well as newly induced kidney tumors were explanted to monolayer cell cultures. Various concentrations of diethylstilbestrol failed to stimulate cell growth or prolong viability, and cells died after two to eight subcultures. This was not secondary to in vitro selection of a hormone-independent cell population, since hormone was required for growth of tumor recycled from cell culture to animals. The presence of an intact stroma seems to be a requisite for estrogen tumorigenesis in the hamster kidney.

📜 SIMILAR VOLUMES

Characteristics of a tumor cell line and
Characteristics of a tumor cell line and virus derived from hamster tumors induced by rauscher leukemia virus-transformed hamster embryo cells
✍ Johng Sik Rhim; R. J. Huebner; R. C. Ting; N. Wivel; W. Vass 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 French ⚖ 884 KB

## Abstract A transplantable hamster tumor (RHT‐1) induced by Rauscher leukemia‐virus‐transformed hamster embryo cells was established in tissue culture, and its characteristics were studied. The tumor cell line also contained group‐specific complement‐fixing antigen and continuously released infec

Depletion of mitochondrial DNA and enzym
Depletion of mitochondrial DNA and enzyme in estrogen-induced hamster kidney tumors: A rodent model of hormonal carcinogenesis
✍ Hari K. Bhat 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

## Abstract Mitochondrial DNA (mtDNA) encodes for 13 polypeptides critical for normal functioning of the electron transport chain and damage to mtDNA has been associated with aging, and implicated in several disease processes. Although damage to mtDNA is being implicated in mutagenesis and carcinog

Immunohistochemical renin study of DES-i
Immunohistochemical renin study of DES-induced renal tumor in the Syrian hamster
✍ Dodge, Alice H. ;Brownfield, Mark ;Reid, Ian A. ;Inagami, Tadashi 📂 Article 📅 1988 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 915 KB

Diethylstilbestrol (DES) treatment of duced enough renin to raise the level of circulating a male Syrian hamster resulted in the development of a renin, plasma renin activity (PRA) was determined for renal tumor and its widely scattered serosal metastases. The Cells in both the primary tumor and me

Effects of carcinogen dose on the charac
Effects of carcinogen dose on the characteristics of the tracheal tumor response induced by N-nitroso-N-methylurea in hamsters
✍ Tsutomu Yarita; Paul Nettesheim 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 513 KB

## Abstract Tracheal tumors were induced by repeated intratracheal exposures to the carcinogen __N__‐nitroso‐__N__‐methylurea (NMU), using a catheter system previously described. Carcinogen concentrations of 0.25, 0.50 and 1.0% were employed in 20 or 30 twice‐weekly exposures. Most of the tumors de