Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative study
β Scribed by N. Bogdanovic; P. Davidsson; I. Volkmann; B. Winblad; K. Blennow
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 1009 KB
- Volume
- 107
- Category
- Article
- ISSN
- 1435-1463
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A combined assay to measure neurite outgrowth and B-50/GAP-43 levels in PC12 cells is reported. During NGF-induced neuritogenesis, B-50/GAP-43 expression was monitored by enzyme-linked immunosorbent assay (ELISA). Neurite outgrowth was quantified at the same time by the use of video image analysis.
## Abstract Accumulating evidence indicates that the heparanβsulfateβproteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to la