Growth arrest specific gene 1: a fuel for driving growth in the cerebellum
โ Scribed by Gregory Marques; Chen-Ming Fan
- Book ID
- 111740946
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 170 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1473-4222
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๐ SIMILAR VOLUMES
## Abstract gasโ1 belongs to a family of growth arrest specific genes negatively regulated after growth induction of arrested cells. We report the expression of gasโ1 in an in vivo system of cell proliferation. gasโ1 mRNA accumulates progressively in the uterus of ovariectomized rats with a peak at
The GAS1 gene product induces growth arrest through a p53-dependent mechanism. To investigate whether GAS1 is a tumor suppressor gene, we transfected GAS1-negative human tumor cells with GAS1 plasmids and analyzed growth characteristics of stable transfectants. When a constitutively expressing GAS1