Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer
β Scribed by Honghong Wang; Xiong Zhou; Yongguo Zhang; Hongwu Zhu; Lina Zhao; Linni Fan; Yingmei Wang; Yi Gang; Kaichun Wu; Zhiguo Liu; Daiming Fan
- Book ID
- 117964096
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 942 KB
- Volume
- 279
- Category
- Article
- ISSN
- 1432-1327
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The GAS1 gene product induces growth arrest through a p53-dependent mechanism. To investigate whether GAS1 is a tumor suppressor gene, we transfected GAS1-negative human tumor cells with GAS1 plasmids and analyzed growth characteristics of stable transfectants. When a constitutively expressing GAS1
## Abstract Activation of tyrosine kinases is an important factor during cancer development. Axl, one of the receptor tyrosine kinases, binds to the specific ligand growth arrestβspecific gene 6 (Gas6), which encodes a vitamin Kβdependent Ξ³βcarboxyglutamyl protein. Although many receptor tyrosine k