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Estrogen-regulated expression of a growth arrest specific gene (gas-1) in rat uterus

✍ Scribed by Marina Ferrero; Gaetano Cairo

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
405 KB
Volume
17
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

gas‐1 belongs to a family of growth arrest specific genes negatively regulated after growth induction of arrested cells. We report the expression of gas‐1 in an in vivo system of cell proliferation. gas‐1 mRNA accumulates progressively in the uterus of ovariectomized rats with a peak at three weeks after surgery. After estrogen treatment gas‐1 mRNA levels decrease within two hours, at a time when c‐myc expression is greatly increased, and return to pretreatment levels at 48 hours. Treatment with cycloheximide does not prevent estrogen‐induced down‐regulation of gas‐1 mRNA levels. The present results show that: i) estrogen affects the uterine growth state by regulating the expression of both positively and negatively acting genes, ii) gas‐1 expression is controlled by cellular growth state also in vivo.

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