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Grignard Additions to 2-Uloses: Synthesis of Stereochemically Pure Tertiary Alcohols.

✍ Scribed by Ed Cleator; Catherine F. McCusker; Frank Steltzer; Steven V. Ley


Book ID
101961529
Publisher
John Wiley and Sons
Year
2004
Weight
159 KB
Volume
35
Category
Article
ISSN
0931-7597

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In the presence of anhydrous cerium(III1 chloride, Grignard reagents react with ketones to afford addition products in high yields, even though the substrates are susceptible to abnormal reactions with Grignard reagents alone. ## The reaction of Grignard reagents with carbonyl Sympounds is well-k