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Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein

✍ Scribed by Haruhiko Akiyama; Claudia Schwab; Hiromi Kondo; Hiroshi Mori; Fuyuki Kametani; Kenji Ikeda; Patrick L. McGeer


Book ID
117475020
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
302 KB
Volume
206
Category
Article
ISSN
0304-3940

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Diffuse amyloid beta-protein (Abeta) deposits with numerous glial cells containing C-terminal Abeta fragments occur in the cerebral cortex of patients with Alzheimer's disease. By using a panel of antibodies specific for various epitopes in the Abeta peptide, we have investigated the immunohistochem