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Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways

โœ Scribed by Manchao Zhang; Hongpeng Liu; Zhenkun Tian; Brian N. Griffith; Min Ji; Q. Quentin Li


Book ID
116718904
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
518 KB
Volume
80
Category
Article
ISSN
0024-3205

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## Abstract Tetracycline analogues (TCNAs) possess cytotoxic activities as well as matrix metalloproteinase (MMP) inhibitory properties. Previously, we demonstrated that doxycycline (DOXY) could induce apoptosis in human HT29 colon cancer cells. In present study, the molecular apoptotic mechanisms