(G)n-Mononucleotide polymorphism in the human D4 dopamine receptor (DRD4) gene
β Scribed by A. Petronis; K. O'Hara; C. L. Barr; J. L. Kennedy; H. H. M. Tol
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 91 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0340-6717
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β¦ Synopsis
Polymorphism in intron I of the human dopamine D4 receptor is described.
π SIMILAR VOLUMES
The dopamine D4 receptor (DRD4) is a member of the D2-like dopamine receptor family. Polymorphisms at the DRD4 gene have been examined for association with a wide range of neuropsychiatric disorders and normal behavioral variation. The DRD4 gene is unusual in its high amount of expressed polymorphis
The term genomic imprinting has been used to refer to the differential expression of genetic material depending on whether it has come from the male or female parent. In humans, the chromosomal region llp15.5 has been shown to contain 2 imprinted genes (H19 and IGF2). The gene for the dopamine D4 re
## Abstract We have examined the hypothesis that a variable number of tandem repeats in the third cytoplasmic loop of the dopamine D4 receptor influences clinical response to clozapine using a sample of 189 schizophrenic patients. Alleles of the 48βbp repeat, which range from two to ten copies in t