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Lack of imprinting of the human dopamine D4 receptor (DRD4) gene

✍ Scribed by Cichon, Sven; Nöthen, Markus M.; Wolf, Helmut K.; Propping, Peter

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
8 KB
Volume
67
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19960409)67:2<229::aid-ajmg17>3.0.co;2-l

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✦ Synopsis

The term genomic imprinting has been used to refer to the differential expression of genetic material depending on whether it has come from the male or female parent. In humans, the chromosomal region llp15.5 has been shown to contain 2 imprinted genes (H19 and IGF2). The gene for the dopamine D4 receptor (DRDU, which is of great interest for research into neuropsychiatric disorders and psychopharmacology, is also located in this area. In the present study, we have examined the imprinting status of the DRD4 gene in brain tissue of an epileptic patient who was heterozygous for a 12 bp repeat polymorphism in exon 1 of the DRD4 gene. W e show that both alleles are expressed in equivalent amounts. W e therefore conclude that the DRD4 gene is not imprinted in the human brain.

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