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Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs

โœ Scribed by Nandurdikar, Rahul S.; Maciag, Anna E.; Hong, Sam Y.; Chakrapani, Harinath; Citro, Michael L.; Keefer, Larry K.; Saavedra, Joseph E.

Book ID
126057388
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
444 KB
Volume
12
Category
Article
ISSN
1523-7060

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An improved synthesis of V-PROLI/NO, a c
An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide prodrug
โœ Sam Y. Hong; Rahul S. Nandurdikar; Larry K. Keefer; Joseph E. Saavedra; Harinath ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 541 KB

An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide (NO) prodrug, in an overall yield of 26% in four steps from prolinol is reported; the previously published yield of this transformation was 1%. Using this revised strategy, the sarcosine analogue ( 14) of V-PROLI/NO was pr