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Bioreductively-Activated Prodrugs of Nitric Oxide (NO)

โœ Scribed by Chakrapani, Harinath; Sharma, Kavita


Book ID
122367073
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
180 KB
Volume
53
Category
Article
ISSN
0891-5849

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An improved synthesis of V-PROLI/NO, a c
โœ Sam Y. Hong; Rahul S. Nandurdikar; Larry K. Keefer; Joseph E. Saavedra; Harinath ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 541 KB

An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide (NO) prodrug, in an overall yield of 26% in four steps from prolinol is reported; the previously published yield of this transformation was 1%. Using this revised strategy, the sarcosine analogue ( 14) of V-PROLI/NO was pr