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V-PROLI/NO, a Prodrug of the Nitric Oxide Donor, PROLI/NO

โœ Scribed by Chakrapani, Harinath; Showalter, Brett M.; Kong, Li; Keefer, Larry K.; Saavedra, Joseph E.

Book ID
126997949
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
80 KB
Volume
9
Category
Article
ISSN
1523-7060

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๐Ÿ“œ SIMILAR VOLUMES

An improved synthesis of V-PROLI/NO, a c
An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide prodrug
โœ Sam Y. Hong; Rahul S. Nandurdikar; Larry K. Keefer; Joseph E. Saavedra; Harinath ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 541 KB

An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide (NO) prodrug, in an overall yield of 26% in four steps from prolinol is reported; the previously published yield of this transformation was 1%. Using this revised strategy, the sarcosine analogue ( 14) of V-PROLI/NO was pr

Injectable formulation of disodium 1-[2-
Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug
โœ David J. Waterhouse; Joseph E. Saavedra; Keith M. Davies; Michael L. Citro; Xia ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 105 KB

PROLI/NO is an agent of structure XN(O)==NONa (X = L-prolyl) whose 2-s half-life for nitric oxide (NO) release at physiological pH makes it an excellent prodrug for localizing NO's therapeutic effects at the site of application, but a difficult one to formulate and certify as pure. Despite its extra