## Abstract Monogenic forms of Parkinson's disease (PD) provide an opportunity to examine mechanisms underlying phenotypic variation. Glutathione S‐transferase (GST) has detoxification and antioxidative functions. To screen genetic variations in GST for an effect on the onset age (OA) of PD, we typ
Glutathione S-transferase polymorphism in Parkinson's disease
✍ Scribed by A. Rahbar; M. Kempkes; Th. Müller; S. Reich; F. L. Welter; S. Meves; H. Przuntek; H. M. Bolt; W. Kuhn
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 49 KB
- Volume
- 107
- Category
- Article
- ISSN
- 1435-1463
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## Abstract We studied genetic polymorphisms in the glutathione‐__S__‐transferase‐1 (GST‐1) gene region and the interleukin‐1β (IL‐1β) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger samp
tribution in PD was 50% GSTp+ (males 53%, females 48%) and 50% GSTp-(males 47%, females 52%). These results were not statistically different from that of the control group. Thus, absence of GSTp is not significantly associated with PD. However, we consider it useful to know not only which detoxifyi
We appreciate the careful reading of our manuscript by Okun and colleagues. 1 However, their letter contains a number of inaccuracies that require correction. We clearly state