We appreciate the careful reading of our manuscript by Okun and colleagues. 1 However, their letter contains a number of inaccuracies that require correction. We clearly state
Glutathion s-transferase (class μ) phenotype in Parkinson's disease
✍ Scribed by F. Tison; C. Coutelle; P. Henry; A. Cassaigne
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 174 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
tribution in PD was 50% GSTp+ (males 53%, females 48%) and 50% GSTp-(males 47%, females 52%). These results were not statistically different from that of the control group.
Thus, absence of GSTp is not significantly associated with PD. However, we consider it useful to know not only which detoxifying pathway defects may be predisposing to PD but also those which may not.
📜 SIMILAR VOLUMES
The glutathione S-transferases (GSTs) catalyze the conjugation of a wide variety of reactive, electrophilic substrates with glutathione, facilitating their excretion. There is also evidence that GSTs can catalyze glutathione conjugation of lipid radicals as well as act in the generation of leukotrie
## Abstract Monogenic forms of Parkinson's disease (PD) provide an opportunity to examine mechanisms underlying phenotypic variation. Glutathione S‐transferase (GST) has detoxification and antioxidative functions. To screen genetic variations in GST for an effect on the onset age (OA) of PD, we typ
## Abstract We studied genetic polymorphisms in the glutathione‐__S__‐transferase‐1 (GST‐1) gene region and the interleukin‐1β (IL‐1β) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger samp
## Abstract The activities of enzymes related to glutathione synthesis, degradation, and function were analyzed in various brain regions (cerebral cortex, caudate nucleus, putamen, globus pallidus, and substantia nigra) from patients dying with pathologically proven Parkinson's disease (PD) and mul