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Glutathione-S-transferase-1 and interleukin-1β gene polymorphisms in Japanese patients with Parkinson's disease

✍ Scribed by Masataka Nishimura; Sadako Kuno; Ryuji Kaji; Katsuhito Yasuno; Hideshi Kawakami

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
50 KB
Volume
20
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We studied genetic polymorphisms in the glutathione‐S‐transferase‐1 (GST‐1) gene region and the interleukin‐1β (IL‐1β) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL‐1β genotype has affected the age at onset of PD patients, no contribution of the GST‐1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons. © 2005 Movement Disorder Society

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The authors thank all patients and blood donors who participated in this study and gratefully acknowledge Dr. H. Olthuis and his staff at the Red Cross Blood Bank of Nijmegen for collecting blood samples from the donors.