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Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy

โœ Scribed by Masataka Nishimura; Sadako Kuno; Ryuji Kaji; Hideshi Kawakami

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
56 KB
Volume
20
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

Abstract

We studied two genetic polymorphisms (240C/T and 480G/A) of the brainโ€derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD. ยฉ 2005 Movement Disorder Society

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