Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and
Plasma glutathione S-transferase P1-1 levels in patients with head and neck squamous cell carcinoma
โ Scribed by Michael B. Oude Ophuis; Theo P. J. Mulder; Wilbert H. M. Peters; Johannes J. Manni
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 83 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
โฆ Synopsis
The authors thank all patients and blood donors who participated in this study and gratefully acknowledge Dr. H. Olthuis and his staff at the Red Cross Blood Bank of Nijmegen for collecting blood samples from the donors.
๐ SIMILAR VOLUMES
Serum and tumor cytosolic levels of glutathione-S-transferase (GST) and glutathione-reductase (GR) activity were determined spectrophotometrically. The levels were correlated with clinicopathological criteria and a tobacco-associated protein band (T band) found in serum. The results showed significa
## Background: Gastrointestinal tumors often contain high amounts of the detoxification enzyme glutathione s-transferase p1-1 (gstp1-1). elevated levels of gstp1-1 were found in serum and plasma from most patients with gastrointestinal tumors. the authors evaluated the role of gstp1-1 as a plasma t
Gm, A2m, and Km allotypic markers were examined in 40 Caucasian patients with squamous cell carcinomas of the head and neck. Serum IgA levels, the A2m(l) allotypic marker, and antibodies against IgAl, A2m(l), and A2m(2) were measured quantitatively. The frequency of Km(1) was found to be significant