๐”– Bobbio Scriptorium
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Glutamate and aspartate mimic the afferent transmitter in the cochlea

โœ Scribed by R. P. Bobbin

Book ID
104676251
Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
253 KB
Volume
34
Category
Article
ISSN
0014-4819

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โœฆ Synopsis

Glutamate (50 mM) and aspartate (50 mM) applied intracochlearly increase the spontaneous activity of ganglion cells of the auditory nerve. This activity may account for the decreased magnitude of the compound action potential observed with these substances in previous studies, and also may be additional evidence that these substances have a role in synaptic transmission between the hair cells and primary auditory afferent nerve cells.

๐Ÿ“œ SIMILAR VOLUMES

Evidence that GABA is not the afferent t
Evidence that GABA is not the afferent transmitter in the cochlea
โœ R. Klinke; W. Oertel ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 227 KB

The GABA antagonists picrotoxin, bicuculline and bicuculline-methochloride, when applied intracochlearly, do not affect the compound action potential of the cochlear nerve. It is therefore concluded that these drugs do not interfere with afferent synaptic transmission, and therefore that GABA is not

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Beta-receptor blocking agents (practolol, propranolol) and alpha-receptor blocking agents (phenoxybenzamine, phentolamine), when applied intracochlearly do not eliminate the afferetn discharges or compound action potential of the cochlear nerve. Under the assumption that the drugs used reach the syn