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Evidence that 5-HT is not the afferent transmitter in the cochlea

✍ Scribed by R. Klinke; W. Oertel

Book ID
104677268
Publisher
Springer-Verlag
Year
1977
Tongue
English
Weight
208 KB
Volume
30
Category
Article
ISSN
0014-4819

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The GABA antagonists picrotoxin, bicuculline and bicuculline-methochloride, when applied intracochlearly, do not affect the compound action potential of the cochlear nerve. It is therefore concluded that these drugs do not interfere with afferent synaptic transmission, and therefore that GABA is not

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Beta-receptor blocking agents (practolol, propranolol) and alpha-receptor blocking agents (phenoxybenzamine, phentolamine), when applied intracochlearly do not eliminate the afferetn discharges or compound action potential of the cochlear nerve. Under the assumption that the drugs used reach the syn