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Glucuronidation versus Oxidation of the Flavonoid Galangin by Human Liver Microsomes and Hepatocytes

✍ Scribed by Otake, Y.

Book ID
118255453
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2002
Tongue
English
Weight
264 KB
Volume
30
Category
Article
ISSN
0090-9556

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✍ Kristian Linnet πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 72 KB

Olanzapine is a widely used, newer antipsychotic agent, which is metabolized by various pathways: hydroxylation and N-demethylation by cytochrome P450, N-oxidation by flavin monooxygenase and direct glucuronidation. In vivo studies have pointed towards the latter pathway as being of major importance