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Glucuronidation of Drugs and Drug-Induced Toxicity in Humanized UDP-Glucuronosyltransferase 1 Mice

✍ Scribed by Kutsuno, Y.; Itoh, T.; Tukey, R. H.; Fujiwara, R.

Book ID
121861040
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2014
Tongue
English
Weight
277 KB
Volume
42
Category
Article
ISSN
0090-9556

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Valproic acid glucuronidation kinetics were carried our with three human UGT isoforms: UGT1A6, UGT1A9, and UGT2B7 as well as human liver and kidney microsomes. The glucuronidation of valproic acid was typified by high K(m) values with microsomes and expressed UGTs (2.3-5.2mM). The ability of valproi