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Effect of Common Exon Variant (p.P364L) on Drug Glucuronidation by the Human UDP-Glucuronosyltransferase 1 Family

โœ Scribed by Yu Mimura; Yoshihiro Maruo; Yoriko Ohta; Hiroshi Sato; Yoshihiro Takeuchi


Book ID
111316994
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
282 KB
Volume
109
Category
Article
ISSN
1742-7835

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The effect of valproic acid on drug and
โœ Brian T Ethell; Gail D Anderson; Brian Burchell ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 187 KB

Valproic acid glucuronidation kinetics were carried our with three human UGT isoforms: UGT1A6, UGT1A9, and UGT2B7 as well as human liver and kidney microsomes. The glucuronidation of valproic acid was typified by high K(m) values with microsomes and expressed UGTs (2.3-5.2mM). The ability of valproi