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Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

✍ Scribed by Hoffer, Barry J.; Hoffman, Alex; Bowenkamp, Kate; Huettl, Peter; Hudson, John; Martin, David; Lin, Leu-Fen H.; Gerhardt, Greg A.

Book ID
120467719
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
444 KB
Volume
182
Category
Article
ISSN
0304-3940

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Parkinson's disease is characterized by the progressive degeneration of midbrain dopaminergic neurons. Several studies have examined the effects of the dopaminergic neurotrophins growth/differentiation factor 5 (GDF5) and glial cell line-derived neurotrophic factor (GDNF) on these neurons in vitro.