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GLC determination of indoprofen in plasma

✍ Scribed by Robert V. Smith; David W. Humphrey; Henry Escalona-Castillo

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 352 KB
Volume: 66
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600660139

No coin nor oath required. For personal study only.

✦ Synopsis

Implementation of human bioavailability studies with the analgesic indoprofen required a rapid, sensitive, and convenient assay in blood plasma. A procedure based on ether extraction of acidified plasma, derivatization with diazomethane, and GLC analysis using a 3% OV-1 column was sufficiently sensitive for measurement of plasma indoprofen concentrations in the 0.4-16 mug/ml range. An average recovery of 99.0 +/- 7.6% (SD) was achieved when the pentanoic acid homolog was employed as an internal standard.

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