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GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells

✍ Scribed by Hanna Igarashi; Yujia Cao; Hideyuki Iwai; Jinhua Piao; Yosuke Kamimura; Masaaki Hashiguchi; Teruo Amagasa; Miyuki Azuma

Book ID: 116296566
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 713 KB
Volume: 369
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2008.03.024

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## Abstract The T cell surface protein CD28 provides a critical costimulatory signal for T cell activation. With age, humans accumulate increasing numbers of CD28^–^ T cells, and this loss of CD28 expression is exacerbated certain disease states, such as HIV infection, autoimmune conditions or canc