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Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

โœ Scribed by Shimizu, Jun; Yamazaki, Sayuri; Takahashi, Takeshi; Ishida, Yasumasa; Sakaguchi, Shimon

Book ID
118676068
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
375 KB
Volume
3
Category
Article
ISSN
1529-2908

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๐Ÿ“œ SIMILAR VOLUMES

Specificity of regulatory CD4+CD25+ T ce
Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants
โœ Abigail C. Buenafe; Laura Tsaknaridis; Leslie Spencer; Kevin S. Hicks; Rachel H. ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 445 KB

## Abstract Although the phenotypic and regulatory properties of the CD4^+^CD25^+^ T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4^+^CD25^+^ Treg population includes the recognition of a broad spectrum of human TCR CDR