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Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1

✍ Scribed by Kwang Youl Lee; Jeong Ae Park; Eunah Chung; You Hui Lee; Shin Kim II; Seung Ki Lee


Book ID
117468385
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
942 KB
Volume
110
Category
Article
ISSN
0304-3835

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio