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Germline mutations inRAD51Cin Jewish high cancer risk families

✍ Scribed by Anya Kushnir, Yael Laitman, Shani Paluch Shimon, Raanan Berger, Eitan Friedman

Book ID
118796804
Publisher
Springer US
Year
2012
Tongue
English
Weight
230 KB
Volume
136
Category
Article
ISSN
0167-6806

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✍ Ella R. Thompson; Samantha E. Boyle; Julie Johnson; Georgina L. Ryland; Sarah Sa πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 180 KB

There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications