Germline mutations at microsatellite loci in homozygous and heterozygous mutants for mismatch repair and PCNA genes in Drosophila
✍ Scribed by A Baida; A López; R Marcos; A Velázquez
- Book ID
- 117798974
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 127 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1568-7864
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DNA mismatch repair is of considerable scientific and medical importance because of its essential role in maintaining genomic integrity, and its association with hereditary non-polyposis colon cancer (HNPCC). Germline mutations in five mismatch repair genes (MLH1, MSH2, PMS1, PMS2, and MSH6) have be