✦ LIBER ✦

Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes

✍ Scribed by Win, A K; Dowty, J G; English, D R; Campbell, P T; Young, J P; Winship, I; Macrae, F A; Lipton, L; Parry, S; Young, G P

Book ID: 109838793
Publisher: Nature Publishing Group
Year: 2011
Tongue: English
Weight: 324 KB
Volume: 105
Category: Article
ISSN: 0007-0920
DOI: 10.1038/bjc.2011.172

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Cancer risk in mutation carriers of DNA-

Cancer risk in mutation carriers of DNA-mismatch-repair genes

✍ Markku Aarnio; Risto Sankila; Eero Pukkala; Reijo Salovaara; Lauri A. Aaltonen; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 46 KB 👁 2 views

Excessive incidence of various cancers is a challenging feature of the hereditary-non-polyposis-colorectal-cancer (HNPCC) syndrome. This study estimated the cancer incidences in HNPCC compared with the general population. Individuals in a cohort of 1763 members of 50 genetically diagnosed families w

Validation of predictive models for germ

Validation of predictive models for germline mutations in DNA mismatch repair genes in colorectal cancer

✍ Jose G. Monzon; Carol Cremin; Linlea Armstrong; Jennifer Nuk; Sean Young; Doug E 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 212 KB 👁 2 views

## Abstract Lynch syndrome is defined by the presence of germline mutations in mismatch repair (MMR) genes. Several models have been recently devised that predict mutation carrier status (Myriad Genetics, Wijnen, Barnetson, PREMM and MMRpro models). Families at moderate‐high risk for harboring a Ly

Germline and somatic mutation analyses i

Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers

✍ Steven M. Lipkin; Victoria Wang; Dan L. Stoler; Garth R. Anderson; Ilan Kirsch; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB 👁 2 views

DNA mismatch repair is of considerable scientific and medical importance because of its essential role in maintaining genomic integrity, and its association with hereditary non-polyposis colon cancer (HNPCC). Germline mutations in five mismatch repair genes (MLH1, MSH2, PMS1, PMS2, and MSH6) have be

A search for germline APC mutations in e

A search for germline APC mutations in early onset colorectal cancer or familial colorectal cancer with normal DNA mismatch repair

✍ Lisa A. Boardman; Shauna Schmidt; Noralene M. Lindor; Larry J. Burgart; Julie M. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 1 views

Dependence of colorectal cancer risk on

Dependence of colorectal cancer risk on the parent-of-origin of mutations in DNA mismatch repair genes

✍ Christine M. van Vliet; James G. Dowty; Jane L. van Vliet; Letitia Smith; Leeann 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 2 views

Genetic diseases associated with dynamic mutations in microsatellite DNA often display parent-of-origin effects (POEs) in which the risk of disease depends on the sex of the parent from whom the disease allele was inherited. Carriers of germline mutations in mismatch repair (MMR) genes have high ris

Does risk of endometrial cancer for wome

Does risk of endometrial cancer for women without a germline mutation in a DNA mismatch repair gene depend on family history of endometrial cancer or colorectal cancer?

✍ Bharati, Rajani; Jenkins, Mark A.; Lindor, Noralane M.; Le Marchand, Loïc; Galli 📂 Article 📅 2014 🏛 Elsevier Science 🌐 English ⚖ 365 KB