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Germline missense mutations in mismatch-repair genes and genetic testing for HNPCC

✍ Scribed by Nickolas Papadopoulos


Book ID
107535673
Publisher
Current Science Inc.
Year
2007
Tongue
English
Weight
166 KB
Volume
3
Category
Article
ISSN
1556-3790

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## Abstract Lynch syndrome is defined by the presence of germline mutations in mismatch repair (MMR) genes. Several models have been recently devised that predict mutation carrier status (Myriad Genetics, Wijnen, Barnetson, PREMM and MMRpro models). Families at moderate‐high risk for harboring a Ly