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Germ-line p53 mutation is uncommon in patients with triple primary cancers

✍ Scribed by Shiseki, Masayuki; Nishikawa, Ryo; Yamamoto, Hiroshi; Ochiai, Atsushi; Sugimura, Haruhiko; Shitara, Nobuyuki; Sameshima, Yuichi; Mizoguchi, Hideaki; Sugimura, Takashi; Yokota, Jun

Book ID
122448657
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
602 KB
Volume
73
Category
Article
ISSN
0304-3835

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## Abstract Epidemiological studies on intracranial tumors have suggested that the observed familial aggregation of a proportion of gliomas may be due to inherited predisposition to their development. In the Li‐Fraumeni syndrome (LFS) associated with germ‐line mutations of the __p53__ gene, nervous