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Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer

✍ Scribed by Elisabeth Adjadj; Martin Schlumberger; Florent de Vathaire

Book ID: 117784933
Publisher: The Lancet
Year: 2009
Tongue: English
Weight: 681 KB
Volume: 10
Category: Article
ISSN: 1470-2045
DOI: 10.1016/s1470-2045(09)70020-8

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## Abstract Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in __XRCC2__ and __XRCC3__ genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated