Geographical distribution of amyotrophic lateral sclerosis with neurofibrillary tangles in the Kii peninsula of Japan

Similar topographical distribution of ne

✍ Maya Mimuro; Yasumasa Kokubo; Shigeki Kuzuhara 📂 Article 📅 2007 🏛 Springer-Verlag 🌐 English ⚖ 596 KB

Similar topographical distribution of ne

✍ Maya Mimuro; Yasumasa Kokubo; Shigeki Kuzuhara 📂 Article 📅 2007 🏛 Springer-Verlag 🌐 English ⚖ 170 KB

Mutation analyses in amyotrophic lateral

Mutation analyses in amyotrophic lateral sclerosis/parkinsonism–dementia complex of the Kii peninsula, Japan

✍ Hiroyuki Tomiyama; Yasumasa Kokubo; Ryogen Sasaki; Yuanzhe Li; Yoko Imamichi; Ma 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB

## Abstract To clarify the genetic background of amyotrophic lateral sclerosis (ALS)/parkinsonism–dementia complex (PDC) of the Kii peninsula, Japan (Kii ALS/PDC), we performed extended mutation analyses of three patients with pathologically diagnosed Kii ALS/PDC. Direct sequencing analyses were pe

Increased oxidative stress in patients w

Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan

✍ Satoru Morimoto; Shigeki Kuzuhara; Yasumasa Kokubo 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 438 KB

## Abstract Amyotrophic lateral sclerosis and Parkinsonism‐dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PD

TRPM7 is not associated with amyotrophic

TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan

✍ Kenju Hara; Yasumasa Kokubo; Hiroyuki Ishiura; Yuko Fukuda; Akinori Miyashita; R 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 83 KB 👁 2 views

## Abstract Amyotrophic lateral sclerosis‐parkinsonism dementia complex (ALS/PDC) is a distinct neurodegenerative disorder characterized by ALS pathology with neurofibrillary tangles (NFTs) in the spinal cord and brain. Recent clinical studies have revealed a high incidence and a high familial occu

Atypical parkinsonism of Japan: Amyotrop

Atypical parkinsonism of Japan: Amyotrophic lateral sclerosis–parkinsonism–dementia complex of the Kii peninsula of Japan (Muro disease): An update

✍ Shigeki Kuzuhara; Yasumasa Kokubo 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB

An update of the endemic parkinsonism-dementia complex (PDC) frequently associated with amyotrophic lateral sclerosis (ALS) in the high prevalence ALS focus of the Kii peninsula of Japan is presented. The initial symptom was parkinsonian gait or hypobulia/amnesia, which was followed by akinesia, rig