Similar topographical distribution of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism–dementia complex in people living in the Kii peninsula of Japan suggests a single tauopathy
✍ Scribed by Maya Mimuro; Yasumasa Kokubo; Shigeki Kuzuhara
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 596 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0001-6322
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📜 SIMILAR VOLUMES
## Abstract To clarify the genetic background of amyotrophic lateral sclerosis (ALS)/parkinsonism–dementia complex (PDC) of the Kii peninsula, Japan (Kii ALS/PDC), we performed extended mutation analyses of three patients with pathologically diagnosed Kii ALS/PDC. Direct sequencing analyses were pe
## Abstract Amyotrophic lateral sclerosis‐parkinsonism dementia complex (ALS/PDC) is a distinct neurodegenerative disorder characterized by ALS pathology with neurofibrillary tangles (NFTs) in the spinal cord and brain. Recent clinical studies have revealed a high incidence and a high familial occu