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Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan

✍ Scribed by Satoru Morimoto; Shigeki Kuzuhara; Yasumasa Kokubo

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
438 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Amyotrophic lateral sclerosis and Parkinsonism‐dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8‐hydroxydeoxyguanosine (8‐OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8‐OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC. © 2008 Movement Disorder Society

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