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Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China

✍ Scribed by D. Forman; F. Sitas; D. G. Newell; A. R. Stacey; J. Boreham; R. Peto; T. C. Campbell; J. Li; J. Chen

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
446 KB
Volume
46
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

To examine the geographic association between Helicobacter pylori infection and gastric cancer, we have assessed the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35‐64 years, in 46 rural counties of the People's Republic of China. The gastric cancer mortality rates in these counties in 1973‐75 varied from 3 per 1,000 (cumulative rate, 0‐64 years) to 69 per 1, 000. while the proportions of the population positive for H. pylori antibodies (based on an average of about 41 men per county) varied from 28% to 96%. After correction for the limited number of blood samples per county, the estimated correlation between H. pyori antibody prevalence and gastric cancer mortality was 40% (p = 0.02). No other type of cancer showed a significant association with H. pylori.

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