Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy
β Scribed by Silvia Mirandola; Giada Sebastiani; Cristina Rossi; Emanuela Velo; Elke Maria Erne; Alessandro Vario; Diego Tempesta; Chiara Romualdi; Davide Campagnolo; Alfredo Alberti
- Book ID
- 119190620
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 337 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0166-3542
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π SIMILAR VOLUMES
Lamivudine is effective in suppressing replication of hepatitis B virus (HBV). However, the emergence of HBV variants resistant to lamivudine is a concern. Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the
## Abstract Lamivudine results in the selection of resistant hepatitis B virus (HBV) variants. Because the surface gene of HBV overlaps completely the polymerase gene, the incidence and profile of surface and polymerase gene mutations were investigated prospectively in chronic HBV patients who were