## Abstract Lamivudine results in the selection of resistant hepatitis B virus (HBV) variants. Because the surface gene of HBV overlaps completely the polymerase gene, the incidence and profile of surface and polymerase gene mutations were investigated prospectively in chronic HBV patients who were
✦ LIBER ✦
Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case
✍ Scribed by Marcelle Bottecchia; Nilo Ikuta; Christian Niel; Natalia M Araujo; Kycia MR Ó; Selma A Gomes
- Book ID
- 108951683
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 177 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0815-9319
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Lamivudine is effective in suppressing replication of hepatitis B virus (HBV). However, the emergence of HBV variants resistant to lamivudine is a concern. Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the
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