Resistance mutations to hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease inhibitors in <1% of the viral quasispecies may still allow >1000-fold viral load reductions upon treatment, consistent with their reported reduced replicative fitness in vitro. Recently, however, an R155K proteas
✦ LIBER ✦
Mutations in hepatitis C virus NS3 protease domain associated with resistance to specific protease inhibitors in antiviral therapy naïve patients
✍ Scribed by Allan Peres-da-Silva; Adilson José de Almeida; Elisabeth Lampe
- Publisher
- Springer Vienna
- Year
- 2010
- Tongue
- English
- Weight
- 458 KB
- Volume
- 155
- Category
- Article
- ISSN
- 1432-8798
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## Abstract This was an exploratory study to investigate lamivudine‐resistant hepatitis B virus (HBV) strains in selected lamivudine‐naïve HBV carriers with and without human immunodeficiency virus (HIV) co‐infection in South African patients. Thirty‐five lamivudine‐naïve HBV infected patients with