Genotype and phenotype of glutathione-s-transferase in patients with head and neck carcinoma
β Scribed by Diemut Konig-Greger; Herbert Riechelmann; Uta Wittich; Silke Gronau
- Book ID
- 116809206
- Publisher
- SAGE Publications
- Year
- 2004
- Tongue
- English
- Weight
- 444 KB
- Volume
- 130
- Category
- Article
- ISSN
- 0194-5998
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π SIMILAR VOLUMES
The authors thank all patients and blood donors who participated in this study and gratefully acknowledge Dr. H. Olthuis and his staff at the Red Cross Blood Bank of Nijmegen for collecting blood samples from the donors.
Background. We sought to evaluate the estimated risk of GSTM1 null genotype and squamous cell carcinoma of the head and neck (SCCHN). Methods. The studies done so far for GSTM1 null genotype as a risk factor associated with head and neck cancer are not conclusive and have shown conflicting results.
Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and