Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.Content:
Chapter 1 Introduction: Genomics and Personalized Medicine (pages 1โ24):
Chapter 2 Genomics Technologies as Tools in Drug Discovery (pages 25โ103):
Chapter 3 Genomic Biomarkers (pages 105โ166):
Chapter 4 Fundamental Principles of Toxicogenomics (pages 167โ217):
Chapter 5 Toxicogenomics: Applications to In Vivo Toxicology (pages 219โ291):
Chapter 6 Toxicogenomics: Applications in In Vitro Systems (pages 293โ327):
Chapter 7 Germ Line Polymorphisms and Drug Response (pages 329โ383):
Chapter 8 Pharmacogenetics of Drug Disposition (pages 385โ421):
Chapter 9 Overview of Regulatory Developments and Initiatives Related to the Use of Genomic Technologies in Drug Discovery and Development (pages 423โ448):
